Eupraxia Pharmaceuticals Reports Symptom Response Data from its Ongoing Phase 1b/2a RESOLVE Trial, Including New Data on Odynophagia (Painful Swallowing) in Eosinophilic Esophagitis Patients

VANCOUVER, British Columbia, Aug. 13, 2026 (GLOBE NEWSWIRE) — Eupraxia Pharmaceuticals Inc. (“Eupraxia” or the “Company”) (NASDAQ:EPRX) (TSX:EPRX), a clinical-stage biotechnology company leveraging its proprietary Diffusphere™ technology designed to optimize local, controlled drug delivery for applications with significant unmet need, today announced positive results from a new analysis of the RESOLVE study examining the effect of EP-104GI on symptom severity, including for the first time an analysis of the effect of EP-104GI on odynophagia (pain when swallowing). This is important because odynophagia scoring is a component of Dysphagia Symptom Questionnaire (DSQ), a commonly used patient reported outcome used in pivotal clinical trials in EoE patients.

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“The results from this analysis of Phase 1b/2a data, which looks at the proportion of patients that exhibit different levels of symptom severity following treatment with EP-104GI, support our previously released results and implies that EP-104GI is having a meaningful effect for EoE patients,” said Dr. Jeymi Tambiah, Chief Medical Officer of Eupraxia. “In our analysis, we looked at symptom severity in measures of dysphagia and odynophagia at baseline through week 52 of the study. In these measures, we saw meaningful shifts in the proportions of patients towards milder scores for their symptoms. Importantly, this is the first time that we have presented data on odynophagia, which is pain experienced when swallowing food. Odynophagia is experienced by many EoE patients and can have a dramatic effect on a patient’s quality of life 1 . In the study there were noted decreases in the number of patients that experienced odynophagia compared to baseline, starting as early as 2 weeks and lasting out to 52 weeks.”

“The results demonstrating that patients treated with EP-104GI experienced an improvement across two distinct measures of symptoms are highly encouraging,” continued Dr. Tambiah. “We are also reassured by the low rates and similar profiles of adverse events across both phases of the trial. In the two portions of the Phase 1b/2 RESOLVE trial, there have been over 130 patients treated with EP-104GI or placebo, which equates to more than 2,000 individual injection sites. We have observed no treatment-emergent or procedure related Serious Adverse Events (SAEs) and have no concerns regarding mean glucose or cortisol levels.”

Dr. James Helliwell, Chief Executive Officer of Eupraxia, said, “What is especially encouraging in this finding is that EP-104GI is continuing to demonstrate consistent biological responses. Patients are seeing improvement in their ability to swallow without food becoming stuck, in the pain they experience with swallowing, in endoscopic findings of disease and histologic severity of disease. These improvements seem to be showing durability to 52 weeks. We continue to anticipate our key Phase 2b placebo-controlled interim readout in Q4 of this year.”