How to Watch 49ers vs. Rams: TV Channel, Live Stream, Time

The San Francisco 49ers and Los Angeles Rams meet Thursday, Sept.

10, 2026, in a first for the league: a regular-season game at Melbourne Cricket Ground in Melbourne, Australia, with kickoff set for 8:35 p.m.

ET.

The same team ended both of their 2025 seasons.

Seattle routed the 49ers 41-6 in the divisional round, then beat the Rams 31-27 in the NFC Championship Game, one win short of Super Bowl LX.

Los Angeles enters 2026 as the outright favorite to win Super Bowl LXI, at +500.

Below, we'll give you all the details you need to know about how to watch this game.

For Los Angeles, the clearest skill position name to watch is Puka Nacua because his availability changed the shape of this matchup.

He was not listed on the Rams injury report released Tuesday after dealing with a core issue, and that points to him being expected to handle his usual role against San Francisco.

That matters in a game where both teams enter 0-0 and there is no 2026 production yet to lean on.

With the Rams still waiting for regular season statistical leaders to emerge, Nacua stands out as a proven focal point whose health is one of the most relevant developments going into this opener.

If he is moving freely, Los Angeles gets a major piece of its passing game back at full strength.

On the San Francisco side, Christian McCaffrey is central because the 49ers expect him to step right back into his regular role.

He was not listed on Tuesday's injury report after his status had been watched through camp, and the latest update points to him being back at 100 percent for this opener.