Jeff Arcuri reveals how 'Bachelorette' wife’s cancer fight transformed his comedy — and their marriage

Life can be uncomfortable.

Jeff Arcuri has built a career on finding the joke in uncomfortable moments.

"I think you can make anything funny.

You can make awkwardness funny if you’re just honest.

People respond to the honesty," the comic told Fox News Digital.

That philosophy has been shaped by nearly two decades of stand-up, but the last few years have tested it in ways Arcuri could not have scripted.

As his career surged toward his first special, "Jeff Arcuri: Nice to Meet You," now streaming on Netflix, his personal life grew more complicated when his wife, "Bachelorette" alumna Katie Thurston, was diagnosed with stage IV breast cancer .

"The past two years with my wife kind of grew me up a little bit," Arcuri said.

"So my comedy kind of matured, and that’s what the special is.

The first half is the stuff that I found funny, and the second half is a lot of s--- that really happened to me." LAWYER-TURNED-SOCIAL MEDIA SENSATION IS BETTING IT ALL ON GOD, LOVE AND GRIEF Rather than rely on material he had accumulated over years, Arcuri said he wanted the special to reflect the reality he was actually living.

"There’s no way I’m going to do a special not talking about what’s going on in my current life right now." Long before Arcuri applied that philosophy to deeply personal material, it was central to the crowd work that helped him gain a following online.

He said he often prefers engaging with someone who appears reluctant to participate rather than the person eager to become part of the show.

"I want him, because now if he laughs, I win," Arcuri said.

"He’s going to answer honestly, thinking it’s going to throw me off.