Christina Applegate says she was misdiagnosed with MS and is now 'back at square one'

Christina Applegate is back at "square one" after doctors told her she does not have multiple sclerosis.

The 54-year-old actress, who was diagnosed with MS in 2021, addressed the surprising development Tuesday on her "MeSsy" podcast with Jamie-Lynn Sigler.

"This may come as great news, but to me, I’m back at square one," Applegate said while fighting back tears.

"It’s hard to say that [my doctor] came into my room, and she said, ‘Congratulations, you don’t have MS.’" KATHIE LEE GIFFORD ADMITS SHE 'WANTED TO DIE' AFTER MISDIAGNOSIS AND MULTIPLE SURGERIES FOR CHRONIC PAIN "What does that moment feel like?" Sigler asked.

"I was, like, not happy at all," Applegate admitted.

"Everybody else was so happy … You don’t get misdiagnosed and then all of a sudden I’m better." "I haven’t gotten better, Jamie!" she continued.

"If anything, I’ve gotten worse in some ways.

So I’m back at square one that I don’t know what’s going on with me." Applegate said her doctors are now working to determine what has caused her ongoing health problems and why she was diagnosed with MS in the first place.

LIKE WHAT YOU'RE READING? CLICK HERE FOR MORE ENTERTAINMENT NEWS "There’s a pretty damn high number of misdiagnoses with MS ," she said.

"So this is not a rare occurrence.

It’s clear now that they’re finding something different.

Something else is going on." The actress also admitted that the news left her feeling confused and as if she had "let everybody down." MICHAEL J.

FOX SAYS GOING PUBLIC WITH PARKINSON'S WAS 'HELL' ON WIFE TRACY POLLAN "It’s this weird feeling of like … I became this — you and I, the poster children for MS," Applegate told Sigler.

"And all that I did, everything I was doing.